Tuesday, December 11, 2012
So I missed my blog birthday again this year! As usual the stats for the past year at Curly Arrow follows below. Thanks to all the blog followers and everyone else who is using the blog. I wish I had more time to post stuff here but running my university research is very time consuming. When I finally get home I really need to do something that isn't chemistry to avoid going insane.
However, the many posts from over the years and the many very valuable comments by the visitors makes this a great resource and forum for exchange of knowledge for students and more experienced chemists. It really is amazing how may people make it here every day in the search for tips and tricks. Merry Christmas and Happy New Year to those of you that are into that stuff, D!
From 18th October 2011 to 18th October 2012:
Absolute unique visitors: 40,669
Total visits: 57,222 (157 visits/day)
Average time on site: 2:27 min
The 10 most frequent visitors identifiable:
(1) Oxford University
(2) Princeton University
(3) Universite de Liege
(4) University of California San Diego
(5) University of Cambridge
(6) Imperial College London
(7) Universidade de Sao Paulo
(8) University of Wisconsin Madison
(9) Stanford University
(10) University of Hull
Top 10 countries that visit the blog:(1) United States
(2) United Kingdom
(10) South Korea
For the past year we have been starting peptidomimetic chemistry up as a new research area in our group. Many chemists believe that peptide chemistry is easy and that peptide chemists aren't "real chemists". However, let me tell you from personal experience that there is absolutely nothing trivial about peptide chemistry. Even short sequences with normal alpha amino acids can be a nightmare to make, troubleshooting is complicated, purification can be a major pain and yields that a small molecule chemist would consider a total fail is generally acceptable in this area of research. Some years ago I was working with a Post Doc that came from Dieter Seebach's lab at ETH. He introduced me to beta amino acids and ever since I have been fascinated by the use of these building blocks in peptidomimetic research. Inspired by the work of Samuel Gellman we are focusing on the use of beta-3 amino acids in combination with alpha amino acids. Consequently, we synthesise beta-3 amino acids to incorporate these in our peptides.
|Silver catalysed Wolff rearragement in a sonicator. Left t = 0 hr; Right t = 2 hr.|
|Diazoinsane clear seal distillation kit purchased from Sigma-Aldrich.|
If you think that playing around with beta-3 amino acids could be fun I can recommend the company Anand Chem based in Slovakia. They produce almost all beta-3 amino acids with the proteinogenic side chains of excellent quality at a highly competitive price. Depending on what they have in stock you may have to wait a couple of weeks for the stuff but it is worth the wait considering the quality and the price. D!