Cisplatin was first described by M. Peyrone in 1845 and this year it celebrates its 30th FDA approval anniversary. D!
Monday, October 13, 2008
Subscribe to:
Post Comments (Atom)
This blog is devoted to the discussion of all aspects of synthetic organic chemistry and related sciences. Curly Arrow is run by a synthetic organic chemist based in Copenhagen, Denmark. Contributions from readers are always welcome and should be emailed to curlyarrow@gmail.com
Curly Arrow
Sweet as a nut!
About Curly Arrow
orcid.org/0000-0003-3926-7047
Followers
Posts
Blogs - that I visit
Labels
Chemistry Journals
- ACS Medicinal Chemistry Letters
- Accounts of Chemical Research
- Aldrichimica Acta
- Angewandte Chemie Int. Ed.
- Beilstein Journal of Organic Chemistry - Open Access!
- Bioorganic and Medicinal Chemistry
- Bioorganic and Medicinal Chemistry Letters
- ChemBioChem
- ChemMedChem
- Chemical Communications
- Chemical Reviews
- Chemical Society Reviews
- Chemistry & Biology
- Chemistry - A European Journal
- Chemistry - An Asian Journal
- European Journal of Medicinal Chemistry
- European Journal of Organic Chemistry
- Helvetica Chimica Acta
- Journal of Chemical Education
- Journal of Medicinal Chemistry
- Journal of Natural Products
- Journal of Organic Chemistry
- Journal of the American Chemical Society
- MedChemComm
- Nature Chemistry
- Organic Letters
- Organic Process Research & Development
- Organic and Biomolecular Chemistry
- PNAS [Proc. Natl. Acad. Sci. U. S. A.]
- RSC Advances
- Synlett
- Synthesis
- Tetrahedron
- Tetrahedron Asymmetry
- Tetrahedron Letters
5 comments:
I for one second that praise.
Good to hear your friend's better, but I still don't think too highly of Cisplatin. What I'm told, its side effects are no fun at all.
Would be nice if we had something as potent but less toxic. Doesn't seem to be an easy wish, though.
there is caboplatin, developed to be a less toxic analogue that does not ruin the kidneys, and oxalplatin and picoplatin etc. Cis platin stil has a superior efficacy.
By the way the original anti-cancer compound identified by accident (anodic oxidation of Pt electrodes that were supposed to be inert) was actually Pt(IV), cis-Pt(NH3)2Cl4 - which is also very potent. The swich to Pt(II) was made because the original Pt(IV) complex had a very poor solubility.
I am about to write a term paper for Biochem that has to be 10-15 pages and i have chosen Cisplatin. I am also giving a speech in my organometallic class about it. I think it is a great coincidence that you wrote about it! Should be fun.
...it is the first medical treatment that involves a transition metal.
Post a Comment