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Monday, October 13, 2008
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This blog is devoted to the discussion of all aspects of synthetic organic chemistry and related sciences. Curly Arrow is run by a synthetic organic chemist based in Copenhagen, Denmark. Contributions from readers are always welcome and should be emailed to curlyarrow@gmail.com
5 comments:
I for one second that praise.
Good to hear your friend's better, but I still don't think too highly of Cisplatin. What I'm told, its side effects are no fun at all.
Would be nice if we had something as potent but less toxic. Doesn't seem to be an easy wish, though.
there is caboplatin, developed to be a less toxic analogue that does not ruin the kidneys, and oxalplatin and picoplatin etc. Cis platin stil has a superior efficacy.
By the way the original anti-cancer compound identified by accident (anodic oxidation of Pt electrodes that were supposed to be inert) was actually Pt(IV), cis-Pt(NH3)2Cl4 - which is also very potent. The swich to Pt(II) was made because the original Pt(IV) complex had a very poor solubility.
I am about to write a term paper for Biochem that has to be 10-15 pages and i have chosen Cisplatin. I am also giving a speech in my organometallic class about it. I think it is a great coincidence that you wrote about it! Should be fun.
...it is the first medical treatment that involves a transition metal.
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