Thursday, March 22, 2007
Wednesday, March 14, 2007
Friday, March 09, 2007
"A University of Washington pharmacology professor pleaded guilty in federal court today to charges of illegally dumping a chemical down a laboratory sink.
Daniel Storm, 62, last June broke open five containers of ethyl ether with an ax and dumped the contents, according to a release by the U.S. Department of Justice. UW health and safety inspectors had surveyed Storm's lab and determined that five containers of ethyl ether, which is highly flammable, needed to be disposed, but Storm didn't want to pay $15,000 out of a lab operations account to get rid of the substance properly. Storm then concealed the dumping, according to the Justice Department.
Under the terms of the plea agreement, prosecutors have recommended Storm be given probation when he is sentenced June 18. He faces a maximum five years in prison and a $250,000 fine.
Storm continues to work at the UW, where he faces an internal disciplinary process."
Well, as this post in The Seattle Times illustrates, it is - quite surprisingly - not too good an idea!
Monday, March 05, 2007
Thursday, March 01, 2007
I have spent a significant part of my life attempting to make cyclopropanes and fancy myself rather knowledgeable in this particular area so you can imagine my surprise when Professor Andy Phillips from University of Colorado mentioned the Kulinkovich cyclopropanation out of the blue (talk entitled: "New Reactions and Strategies for the Synthesis of Complex Natural Products"). I have to admit that I was a full-on Kulinkovich virgin. It's a pretty funky reaction producing 1,1,2-trisubstituted hydroxy-cyclopropanes. These are generally not easy to make so I'm surprised I hadn't seen this stuff before. I'm not sure if anyone has attempted to make an asymmetric version of the reaction but in any event using optically active starting materials Professor Phillips Group managed to make optically active stuff (see below).
I didn't get the yield or dr and I don't know if the stuff has been published yet. However, there's a nice entry in Organic Syntheses (OS) on the Kulinkovich cyclopropanation giving two examples (71 and 80% yield to give one diastereoisomer) as well as some background and the mechanism (see mechanistic explanation from OS below).